Iziqalo zeTransdermal zithola ukuthandwa njengendlela yokulethwa kwezidakamizwa. Ngokungafani nezindlela zendabuko zokuphuza imishanguzo ngomlomo, ama-transdermal patches avumela izidakamizwa ukuthi zidlule ngqo esikhunjeni egazini. Le ndlela entsha yokulethwa kwezidakamizwa iye yaba nomthelela omkhulu emhlabeni wezokwelapha, futhi sebephumelele emnyakeni edlule. Kulesi sihloko, sihlola iniiziqeshana ze-transdermalkukhona nokuthi benziwa kanjani.
Izisekelo zeIziqeshana ze-transdermal
Ama-transdermal patches ama-patches amancane ahamba esikhunjeni. Ziqukethe umuthi okhishwe kancane kancane egazini esikhunjeni. I-patch iqukethe izingqimba ezine eziyisisekelo: ungqimba olusekelayo, ungqimba lwe-membrane, ungqimba lweresivu yezidakamizwa, kanye nongqimba olunamathela. Ungqimba olusekelayo lusebenza njengesithiyo esivikelayo, ngenkathi ungqimba lweRed Reservoir luqukethe umuthi. Isendlalelo esinamathela sigcina isichibi esiphephile endaweni, ngenkathi ungqimba lwefilimu lilawula izinga lapho kukhululwa khona umuthi.
Yiziphi izithako ezifundeni eziguqukayo?
Ama-Transdermal Patches aqukethe uhla lwezithako, ngokuya ngesidakamizwa abasiletha khona. Kodwa-ke, ezinye izithako ezivame kakhulu zihlanganisa amakhompiyutha emithi, ama-polymers, izikhuthazo zokungena, amabhinde, nama-solvents. I-Compound yezemithi isithako esisebenzayo esinikeza isidakamizwa. Ama-polymers, ngakolunye uhlangothi, asetshenziswa kwinqubo yokukhiqiza ukuze adale izingqimba zezinsalela zezidakamizwa. Izithuthukisi zokungena zingezwa ukukhulisa izinga lokukhishwa kwezidakamizwa. Adhesives asetshenziselwa ukuqinisekisa ukuthi isichibi siphethwe ngokuphephile endaweni, ngenkathi i-solvents isetshenziselwa ukuqeda i-compound yezidakamizwa nosizo kwinqubo yokukhiqiza.
Inqubo yokukhiqiza yeiziqeshana ze-transdermal
Inqubo yokukhiqiza yeTransdermal Patches iyinqubo eyinkimbinkimbi ehilela izigaba eziningi. Isigaba sokuqala sibandakanya ukulungiselela ukusekela ungqimba olusekelayo, kuvame ukwenziwa ngefilimu yepulasitiki. Isigaba esilandelayo sibandakanya ukulungiselela ungqimba lweReg Reservor, oluqukethe i-matrix ye-polymer equkethe isithako esisebenzayo. Usendlalelo we-Drug Reservoir uleso sikhathi athuthelwa engqikelweni elisekelayo.
Lapho isendlalelo seReg Reservoir sehlisiwe engxenyeni esele esele, ungqimba olunamathela. Isendlalelo esinamathela ngokuvamile siqukethe ukunamathela okubucayi okubonakalayo okusetshenzisiwe kungqimba elincanyana usebenzisa inqubo yokuhambisa isixazululo. Isigaba sokugcina sibandakanya ukusetshenziswa kwesendlalelo se-membrane, okuvame ukwenziwa ngento evunyelwe noma ye-microporous. Isendlalelo sefilimu silawula izinga lapho umuthi ukhululwa khona esigabeni.
Ekuphetheni,iziqeshana ze-transdermalUguqule imboni yezokwelapha, enikeza indlela entsha yokuletha izidakamizwa. Inqubo yokulungiselela ama-transdermal patches iyinkimbinkimbi futhi ifaka izigaba eziningi, kufaka phakathi ukulungiswa kwesendlalelo sokusekelayo, ungqimba lwe-Drug Reservoriir, ungqimba olunamathela. Yize ama-transdermal patches aqukethe izithako ezahlukahlukene, kufaka phakathi amakhompiyutha wezidakamizwa, ama-polymers, amabhande kanye nama-sol, impumelelo yabo ilele emandleni abo okuletha izidakamizwa ngqo egazini abaningi. Ukukhiqizwa kwama-transdermal patches kuzobucaceke ngokwengeziwe njengoba kuthuthukiswa ngokwezobuchwepheshe, okwenza ukuba kube yithuluzi elibaluleke kakhulu lokulethwa kwezidakamizwa.
Isikhathi sePosi: Meyi-16-2023